6NM4
Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS205 |
| A | CYS208 |
| A | CYS216 |
| A | HIS219 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SAM A 402 |
| Chain | Residue |
| A | TYR318 |
| A | VAL319 |
| A | ASN320 |
| A | CYS321 |
| A | KS7403 |
| A | ALA256 |
| A | LEU258 |
| A | GLY290 |
| A | TYR291 |
| A | ARG317 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue KS7 A 403 |
| Chain | Residue |
| A | GLY290 |
| A | SER292 |
| A | TRP293 |
| A | CYS321 |
| A | ALA322 |
| A | ASP324 |
| A | TRP356 |
| A | TYR361 |
| A | SAM402 |
| A | HOH507 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS205 |
| B | CYS208 |
| B | CYS216 |
| B | HIS219 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue SAM B 402 |
| Chain | Residue |
| B | ALA256 |
| B | GLY257 |
| B | LEU258 |
| B | GLY290 |
| B | TYR291 |
| B | ARG317 |
| B | TYR318 |
| B | VAL319 |
| B | ASN320 |
| B | CYS321 |
| B | KS7403 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue KS7 B 403 |
| Chain | Residue |
| A | ASP214 |
| A | SER215 |
| A | ALA217 |
| A | ALA218 |
| A | PRO221 |
| B | GLY290 |
| B | SER292 |
| B | TRP293 |
| B | ALA322 |
| B | ASP324 |
| B | ASP325 |
| B | TRP356 |
| B | SAM402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24095733","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2019","submissionDatabase":"PDB data bank","title":"Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor.","authors":["Ivanochko D.","Halabelian L.","Fischer C.","Sanders J.M.","Kattar S.D.","Brown P.J.","Edwards A.M.","Bountra C.","Arrowsmith C.H."]}},{"source":"PDB","id":"4IJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NM4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2019","submissionDatabase":"PDB data bank","title":"Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor.","authors":["Ivanochko D.","Halabelian L.","Fischer C.","Sanders J.M.","Kattar S.D.","Brown P.J.","Edwards A.M.","Bountra C.","Arrowsmith C.H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96EQ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q96EQ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"Q96EQ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
