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6NL0

Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CF2 analogue of dGTP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1TDNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3')polymer164861.21Homo sapiens
2PDNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*TP*(2DT))-3')polymer103035.01Homo sapiens
3DDNA (5'-D(P*TP*TP*CP*GP*G)-3')polymer51511.01Homo sapiens
4ADNA polymerase betapolymer33538243.71UniProt (P06746)
Pfam (PF14716)
Pfam (PF10391)
Pfam (PF14792)
Pfam (PF14791)
In PDB
Homo sapiens (Human)
5AMAGNESIUM IONnon-polymer24.31Chemie (MG)
6ASODIUM IONnon-polymer23.03Chemie (NA)
7A2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINEnon-polymer541.21Chemie (GFF)
8ACHLORIDE IONnon-polymer35.51Chemie (CL)
9waterwater18.0233Chemie (HOH)
Sequence modifications
A: 1 - 335 (UniProt: P06746)
PDBExternal DatabaseDetails
Met 289Lys 289engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight47650.9
Non-Polymers*Number of molecules6
Total formula weight669.9
All*Total formula weight48320.8
*Water molecules are not included.

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PDB entries from 2024-07-17

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