6NIG
Crystal structure of the human TLR2-Diprovocim complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Toll-like receptor 2,Variable lymphocyte receptor B | polymer | 576 | 65277.6 | 4 | UniProt (O60603) UniProt (Q2YE02) Pfam (PF13855) | Homo sapiens (Human) | Toll/interleukin-1 receptor-like protein 4 |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | I, N, Q, S (A, B, C, D) | (3S,4S,3'S,4'S)-1,1'-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxami de} | non-polymer | 909.1 | 4 | Chemie (KQD) PubChem (145434438) PubChem (134817267) PubChem (137553173) PubChem (141724697) PubChem (141724837) PubChem (141724800) PubChem (141724713) PubChem (146160876) PubChem (149615321) PubChem (154586711) PubChem (154970981) PubChem (141724698) PubChem (141724773) PubChem (141724814) | |||
| 4 | J, K, L, M, O... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 5 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 507 (UniProt: O60603)
A, B, C, D: 509 - 576 (UniProt: Q2YE02)
| PDB | External Database | Details |
|---|---|---|
| Arg 508 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 261110.6 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 5627.2 | |
| All* | Total formula weight | 268435.4 |
