6NEC
STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35708.2 | 2 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | C, F (A, C) | methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | non-polymer | 539.6 | 2 | Chemie (XIN) | |||
| 3 | D, E (A, C) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, C: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71416.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1171.3 | |
| All* | Total formula weight | 72587.8 |
