6NEC
STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35708.2 | 2 | UniProt (P07949) Pfam (PF07714) In PDB | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
2 | A, C | methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | non-polymer | 539.6 | 2 | Chemie (XIN) | |||
3 | A, C | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
4 | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, C: 705 - 1013 (UniProt: P07949)
PDB | External Database | Details |
---|---|---|
Gly 700 | - | expression tag |
Pro 701 | - | expression tag |
Leu 702 | - | expression tag |
Ser 703 | - | expression tag |
Leu 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71416.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1171.3 | |
All* | Total formula weight | 72587.8 |