6NDZ
Designed repeat protein in complex with Fz8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Frizzled-8 | polymer | 125 | 14602.7 | 3 | UniProt (Q9H461) Pfam (PF01392) | Homo sapiens (Human) | hFz8 |
| 2 | B, D, F (B, D, F) | Designed repeat binding protein | polymer | 200 | 20862.9 | 3 | Escherichia coli | ||
| 3 | G, L, M, N (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 4 | Chemie (MPD) | |||
| 4 | H, I, J, O (A, C) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 5 | K, P (A, F) | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
| 6 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, C, E: 5 - 123 (UniProt: Q9H461)
| PDB | External Database | Details |
|---|---|---|
| Gln 22 | Asn 49 | engineered mutation |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
| His 126 | - | expression tag |
| His 127 | - | expression tag |
| His 128 | - | expression tag |
| His 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 106397.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 829.0 | |
| All* | Total formula weight | 107226.0 |
