6NDZ

Designed repeat protein in complex with Fz8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E	Frizzled-8	polymer	125	14602.7	3	UniProt (Q9H461) Pfam (PF01392) In PDB	Homo sapiens (Human)	hFz8
2	B, D, F	Designed repeat binding protein	polymer	200	20862.9	3		Escherichia coli
3	A, B	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	4	Chemie (MPD)
4	A, C	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
5	A, F	ACETIC ACID	non-polymer		60.1	2	Chemie (ACY)
6		water	water		18.0	215	Chemie (HOH)

Sequence modifications

A, C, E: 5 - 123 (UniProt: Q9H461)

PDB	External Database	Details
Gln 22	Asn 49	engineered mutation
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	106397.0
Non-Polymers*	Number of molecules	10
	Total formula weight	829.0
All*	Total formula weight	107226.0

*Water molecules are not included.