6NCO
Fragment-based Discovery of an apoE4 Stabilizer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Apolipoprotein E | polymer | 185 | 21523.2 | 1 | UniProt (P02649) Pfam (PF01442) In PDB | Homo sapiens (Human) | Apo-E |
2 | A | 1-[5-chloro-4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]cyclobutane-1-carboximidamide | non-polymer | 342.9 | 1 | Chemie (KQP) | |||
3 | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 1 - 162 (UniProt: P02649)
PDB | External Database | Details |
---|---|---|
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Ser -10 | - | expression tag |
Ser -9 | - | expression tag |
Gly -8 | - | expression tag |
Leu -7 | - | expression tag |
Val -6 | - | expression tag |
Pro -5 | - | expression tag |
Arg -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
Arg 112 | Cys 131 | variant |
Gln 163 | - | expression tag |
Ala 164 | - | expression tag |
Gly 165 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 21523.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 342.9 | |
All* | Total formula weight | 21866.1 |