6NCF
The structure of Stable-5-Lipoxygenase bound to AKBA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Arachidonate 5-lipoxygenase | polymer | 691 | 79436.2 | 4 | UniProt (P09917) Pfam (PF01477) Pfam (PF00305) In PDB | Homo sapiens (Human) | 5-lipoxygenase |
2 | A, B, C, D | FE (II) ION | non-polymer | 55.8 | 4 | Chemie (FE2) | |||
3 | B | (3alpha,8alpha,17alpha,18alpha)-3-(acetyloxy)-11-oxours-12-en-23-oic acid | non-polymer | 512.7 | 1 | Chemie (AF7) |
Sequence modifications
A, B, C, D: 3 - 673 (UniProt: P09917)
PDB | External Database | Details |
---|---|---|
Met -17 | - | initiating methionine |
Gly -16 | - | expression tag |
Ser -15 | - | expression tag |
Ser -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Ser -7 | - | expression tag |
Ser -6 | - | expression tag |
Gly -5 | - | expression tag |
Leu -4 | - | expression tag |
Val -3 | - | expression tag |
Pro -2 | - | expression tag |
Arg -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
His 2 | - | expression tag |
Glu 16 | Trp 14 | engineered mutation |
His 17 | Phe 15 | engineered mutation |
- | Pro 41 | SEE REMARK 999 |
- | Phe 42 | SEE REMARK 999 |
- | Tyr 43 | SEE REMARK 999 |
Gly 43 | Asn 44 | SEE REMARK 999 |
Ser 44 | Asp 45 | SEE REMARK 999 |
Gly 75 | Trp 76 | engineered mutation |
Ser 76 | Leu 77 | engineered mutation |
Ala 240 | Cys 241 | engineered mutation |
Ala 561 | Cys 562 | engineered mutation |
Glu 653 | Lys 654 | engineered mutation |
Asn 654 | Lys 655 | engineered mutation |
Leu 655 | Lys 656 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 317745.0 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 736.1 | |
All* | Total formula weight | 318481.1 |