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6NCF

The structure of Stable-5-Lipoxygenase bound to AKBA

Functional Information from GO Data
ChainGOidnamespacecontents
A0001676biological_processlong-chain fatty acid metabolic process
A0001937biological_processnegative regulation of endothelial cell proliferation
A0002232biological_processleukocyte chemotaxis involved in inflammatory response
A0002523biological_processleukocyte migration involved in inflammatory response
A0002540biological_processleukotriene production involved in inflammatory response
A0004051molecular_functionarachidonate 5-lipoxygenase activity
A0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005641cellular_componentnuclear envelope lumen
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006690biological_processicosanoid metabolic process
A0006691biological_processleukotriene metabolic process
A0006954biological_processinflammatory response
A0006959biological_processhumoral immune response
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016525biological_processnegative regulation of angiogenesis
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0016787molecular_functionhydrolase activity
A0019369biological_processarachidonic acid metabolic process
A0019370biological_processleukotriene biosynthetic process
A0019372biological_processlipoxygenase pathway
A0030501biological_processpositive regulation of bone mineralization
A0031965cellular_componentnuclear membrane
A0034440biological_processlipid oxidation
A0034774cellular_componentsecretory granule lumen
A0036336biological_processdendritic cell migration
A0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
A0042593biological_processglucose homeostasis
A0042759biological_processlong-chain fatty acid biosynthetic process
A0045598biological_processregulation of fat cell differentiation
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050727biological_processregulation of inflammatory response
A0050728biological_processnegative regulation of inflammatory response
A0050796biological_processregulation of insulin secretion
A0051213molecular_functiondioxygenase activity
A0061044biological_processnegative regulation of vascular wound healing
A0061045biological_processnegative regulation of wound healing
A0106014biological_processregulation of inflammatory response to wounding
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1900407biological_processregulation of cellular response to oxidative stress
A1901753biological_processleukotriene A4 biosynthetic process
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1903573biological_processnegative regulation of response to endoplasmic reticulum stress
A1903671biological_processnegative regulation of sprouting angiogenesis
A1904813cellular_componentficolin-1-rich granule lumen
A1904999biological_processpositive regulation of leukocyte adhesion to arterial endothelial cell
A2001301biological_processlipoxin biosynthetic process
B0001676biological_processlong-chain fatty acid metabolic process
B0001937biological_processnegative regulation of endothelial cell proliferation
B0002232biological_processleukocyte chemotaxis involved in inflammatory response
B0002523biological_processleukocyte migration involved in inflammatory response
B0002540biological_processleukotriene production involved in inflammatory response
B0004051molecular_functionarachidonate 5-lipoxygenase activity
B0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005641cellular_componentnuclear envelope lumen
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006690biological_processicosanoid metabolic process
B0006691biological_processleukotriene metabolic process
B0006954biological_processinflammatory response
B0006959biological_processhumoral immune response
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016525biological_processnegative regulation of angiogenesis
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0016787molecular_functionhydrolase activity
B0019369biological_processarachidonic acid metabolic process
B0019370biological_processleukotriene biosynthetic process
B0019372biological_processlipoxygenase pathway
B0030501biological_processpositive regulation of bone mineralization
B0031965cellular_componentnuclear membrane
B0034440biological_processlipid oxidation
B0034774cellular_componentsecretory granule lumen
B0036336biological_processdendritic cell migration
B0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
B0042593biological_processglucose homeostasis
B0042759biological_processlong-chain fatty acid biosynthetic process
B0045598biological_processregulation of fat cell differentiation
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050727biological_processregulation of inflammatory response
B0050728biological_processnegative regulation of inflammatory response
B0050796biological_processregulation of insulin secretion
B0051213molecular_functiondioxygenase activity
B0061044biological_processnegative regulation of vascular wound healing
B0061045biological_processnegative regulation of wound healing
B0106014biological_processregulation of inflammatory response to wounding
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1900407biological_processregulation of cellular response to oxidative stress
B1901753biological_processleukotriene A4 biosynthetic process
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1903573biological_processnegative regulation of response to endoplasmic reticulum stress
B1903671biological_processnegative regulation of sprouting angiogenesis
B1904813cellular_componentficolin-1-rich granule lumen
B1904999biological_processpositive regulation of leukocyte adhesion to arterial endothelial cell
B2001301biological_processlipoxin biosynthetic process
C0001676biological_processlong-chain fatty acid metabolic process
C0001937biological_processnegative regulation of endothelial cell proliferation
C0002232biological_processleukocyte chemotaxis involved in inflammatory response
C0002523biological_processleukocyte migration involved in inflammatory response
C0002540biological_processleukotriene production involved in inflammatory response
C0004051molecular_functionarachidonate 5-lipoxygenase activity
C0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005641cellular_componentnuclear envelope lumen
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006690biological_processicosanoid metabolic process
C0006691biological_processleukotriene metabolic process
C0006954biological_processinflammatory response
C0006959biological_processhumoral immune response
C0016020cellular_componentmembrane
C0016363cellular_componentnuclear matrix
C0016525biological_processnegative regulation of angiogenesis
C0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C0016787molecular_functionhydrolase activity
C0019369biological_processarachidonic acid metabolic process
C0019370biological_processleukotriene biosynthetic process
C0019372biological_processlipoxygenase pathway
C0030501biological_processpositive regulation of bone mineralization
C0031965cellular_componentnuclear membrane
C0034440biological_processlipid oxidation
C0034774cellular_componentsecretory granule lumen
C0036336biological_processdendritic cell migration
C0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
C0042593biological_processglucose homeostasis
C0042759biological_processlong-chain fatty acid biosynthetic process
C0045598biological_processregulation of fat cell differentiation
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050727biological_processregulation of inflammatory response
C0050728biological_processnegative regulation of inflammatory response
C0050796biological_processregulation of insulin secretion
C0051213molecular_functiondioxygenase activity
C0061044biological_processnegative regulation of vascular wound healing
C0061045biological_processnegative regulation of wound healing
C0106014biological_processregulation of inflammatory response to wounding
C1900015biological_processregulation of cytokine production involved in inflammatory response
C1900407biological_processregulation of cellular response to oxidative stress
C1901753biological_processleukotriene A4 biosynthetic process
C1903426biological_processregulation of reactive oxygen species biosynthetic process
C1903573biological_processnegative regulation of response to endoplasmic reticulum stress
C1903671biological_processnegative regulation of sprouting angiogenesis
C1904813cellular_componentficolin-1-rich granule lumen
C1904999biological_processpositive regulation of leukocyte adhesion to arterial endothelial cell
C2001301biological_processlipoxin biosynthetic process
D0001676biological_processlong-chain fatty acid metabolic process
D0001937biological_processnegative regulation of endothelial cell proliferation
D0002232biological_processleukocyte chemotaxis involved in inflammatory response
D0002523biological_processleukocyte migration involved in inflammatory response
D0002540biological_processleukotriene production involved in inflammatory response
D0004051molecular_functionarachidonate 5-lipoxygenase activity
D0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
D0005506molecular_functioniron ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005641cellular_componentnuclear envelope lumen
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006690biological_processicosanoid metabolic process
D0006691biological_processleukotriene metabolic process
D0006954biological_processinflammatory response
D0006959biological_processhumoral immune response
D0016020cellular_componentmembrane
D0016363cellular_componentnuclear matrix
D0016525biological_processnegative regulation of angiogenesis
D0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D0016787molecular_functionhydrolase activity
D0019369biological_processarachidonic acid metabolic process
D0019370biological_processleukotriene biosynthetic process
D0019372biological_processlipoxygenase pathway
D0030501biological_processpositive regulation of bone mineralization
D0031965cellular_componentnuclear membrane
D0034440biological_processlipid oxidation
D0034774cellular_componentsecretory granule lumen
D0036336biological_processdendritic cell migration
D0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
D0042593biological_processglucose homeostasis
D0042759biological_processlong-chain fatty acid biosynthetic process
D0045598biological_processregulation of fat cell differentiation
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050727biological_processregulation of inflammatory response
D0050728biological_processnegative regulation of inflammatory response
D0050796biological_processregulation of insulin secretion
D0051213molecular_functiondioxygenase activity
D0061044biological_processnegative regulation of vascular wound healing
D0061045biological_processnegative regulation of wound healing
D0106014biological_processregulation of inflammatory response to wounding
D1900015biological_processregulation of cytokine production involved in inflammatory response
D1900407biological_processregulation of cellular response to oxidative stress
D1901753biological_processleukotriene A4 biosynthetic process
D1903426biological_processregulation of reactive oxygen species biosynthetic process
D1903573biological_processnegative regulation of response to endoplasmic reticulum stress
D1903671biological_processnegative regulation of sprouting angiogenesis
D1904813cellular_componentficolin-1-rich granule lumen
D1904999biological_processpositive regulation of leukocyte adhesion to arterial endothelial cell
D2001301biological_processlipoxin biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue FE2 A 701
ChainResidue
AHIS367
AHIS372
AHIS550
AASN554
AILE673

site_idAC2
Number of Residues5
Detailsbinding site for residue FE2 B 701
ChainResidue
BILE673
BHIS367
BHIS372
BHIS550
BASN554

site_idAC3
Number of Residues5
Detailsbinding site for residue FE2 C 701
ChainResidue
CHIS367
CHIS372
CHIS550
CASN554
CILE673

site_idAC4
Number of Residues4
Detailsbinding site for residue FE2 D 701
ChainResidue
DHIS367
DHIS372
DHIS550
DILE673

site_idAC5
Number of Residues16
Detailsbinding site for Di-peptide AF7 B 702 and HIS B 130
ChainResidue
BLEU66
BARG68
BARG101
BGLU108
BVAL109
BVAL110
BILE126
BLEU127
BLYS128
BGLN129
BARG131
BARG132
BLYS133
BGLU134
BTHR137
BARG138

Functional Information from PROSITE/UniProt
site_idPS00081
Number of Residues11
DetailsLIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. VHPIfKLLvAH
ChainResidueDetails
AVAL389-HIS399

site_idPS00711
Number of Residues15
DetailsLIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQtitHlLRTHLVsE
ChainResidueDetails
AHIS362-GLU376

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BARG47
BALA49
BTYR81
BLEU82
CGLY19
CTHR20
CASP21
CGLU46
CARG47
CALA49
CTYR81
CLEU82
DGLY19
DTHR20
DASP21
DGLU46
DARG47
DALA49
DTYR81
DLEU82
BTHR20
BASP21
BGLU46
AGLY19
ATHR20
AASP21
AGLU46
AARG47
AALA49
ATYR81
ALEU82
BGLY19

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0007744|PDB:3O8Y, ECO:0007744|PDB:3V92, ECO:0007744|PDB:3V98, ECO:0007744|PDB:3V99
ChainResidueDetails
CARG370
CSER375
CVAL553
DARG370
DSER375
DVAL553
BARG370
BSER375
BVAL553
AARG370
ASER375
AVAL553

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0007744|PDB:3O8Y, ECO:0007744|PDB:3V92, ECO:0007744|PDB:3V99
ChainResidueDetails
BGLN557
CGLN557
DGLN557
AGLN557

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Essential for stabilizing binding to COTL1 => ECO:0000269|PubMed:19807693
ChainResidueDetails
BGLY105
CGLY105
DGLY105
AGLY105

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine; by MAPKAPK2 => ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:18978352
ChainResidueDetails
BGLN274
CGLN274
DGLN274
AGLN274

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15280375, ECO:0000269|PubMed:26210919
ChainResidueDetails
APRO526
BPRO526
CPRO526
DPRO526

219869

PDB entries from 2024-05-15

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