6N4Y
Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Metabotropic glutamate receptor 5 | polymer | 596 | 67395.6 | 4 | UniProt (P41594) Pfam (PF01094) Pfam (PF07562) | Homo sapiens (Human) | mGluR5 |
| 2 | E, F, G, H (E, F, G, H) | Nanobody 43 | polymer | 123 | 13354.7 | 4 | Lama glama | ||
| 3 | I (I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 4 | J (J) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1203.1 | 1 | In PDB GlyTouCan (G11460AB) | |||
| 5 | K (K) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G86023QJ) | |||
| 6 | L (L) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1041.0 | 1 | In PDB GlyTouCan (G88303DD) | |||
| 7 | M, N, O, P (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 21 - 571 (UniProt: P41594)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| Leu -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Val -13 | - | expression tag |
| Asn -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| Gln -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Glu -3 | - | expression tag |
| His -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Lys 1 | - | expression tag |
| Met 2 | - | expression tag |
| Val 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Ile 6 | - | expression tag |
| Val 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Tyr 9 | - | expression tag |
| Val 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Ala 15 | - | expression tag |
| Ala 16 | - | expression tag |
| His 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Phe 20 | - | expression tag |
| His 572 | - | expression tag |
| His 573 | - | expression tag |
| His 574 | - | expression tag |
| His 575 | - | expression tag |
| His 576 | - | expression tag |
| His 577 | - | expression tag |
| His 578 | - | expression tag |
| His 579 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 323001.2 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3709.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 327595.5 |
