6N2E

Crystal Structure of Human Protocadherin-15 EC1-3 G16D N369D Q370N and Mouse Cadherin-23 EC1-2 T15E

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protocadherin-15	polymer	379	43069.2	2	UniProt (A0A087X1T6) Pfam (PF18432) Pfam (PF00028) UniProt (by SIFTS) (Q96QU1)	Homo sapiens (Human)
2	C, D (C, D)	Cadherin-23	polymer	214	23884.4	2	UniProt (Q99PF4) Pfam (PF00028)	Mus musculus (Mouse)	Otocadherin
3	E, F, G, H, I... (A, B, C, D)	CALCIUM ION	non-polymer		40.1	18	Chemie (CA)
4	W, X, Y, Z (A, B, C, D)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A, B: 1 - 371 (UniProt: A0A087X1T6)

PDB	External Database	Details
Met 0	-	initiating methionine
Asp 16	Gly 42	engineered mutation
Asp 369	Asn 395	engineered mutation
Asn 370	Gln 396	engineered mutation
Leu 371	-	expression tag
Glu 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag

C, D: 1 - 205 (UniProt: Q99PF4)

PDB	External Database	Details
Met 0	-	initiating methionine
Glu 15	Thr 38	engineered mutation
Leu 206	-	expression tag
Glu 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	133907.2
Non-Polymers*	Number of molecules	18
	Total formula weight	721.4
All*	Total formula weight	134628.6

*Water molecules are not included.