6MXD

Crystal structure of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with IMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hypoxanthine-guanine phosphoribosyltransferase, putative	polymer	272	30639.0	4	UniProt (Q38CA1) Pfam (PF00156)	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
2	E, G, I, K (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP)
3	F, H, J (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	L, M, N, O (A, B, C, D)	water	water		18.0	22	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 234 (UniProt: Q38CA1)

PDB	External Database	Details
Met -37	-	expression tag
Gly -36	-	expression tag
Ser -35	-	expression tag
Ser -34	-	expression tag
His -33	-	expression tag
His -32	-	expression tag
His -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
Asp -27	-	expression tag
Tyr -26	-	expression tag
Asp -25	-	expression tag
Ile -24	-	expression tag
Pro -23	-	expression tag
Thr -22	-	expression tag
Thr -21	-	expression tag
Glu -20	-	expression tag
Asn -19	-	expression tag
Leu -18	-	expression tag
Tyr -17	-	expression tag
Phe -16	-	expression tag
Gln -15	-	expression tag
Gly -14	-	expression tag
His -13	-	expression tag
Met -12	-	expression tag
Ala -11	-	expression tag
Ser -10	-	expression tag
Met -9	-	expression tag
Thr -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gln -5	-	expression tag
Gln -4	-	expression tag
Met -3	-	expression tag
Gly -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	122556.0
Non-Polymers*	Number of molecules	7
	Total formula weight	1465.7
All*	Total formula weight	124021.7

*Water molecules are not included.