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6MXD

Crystal structure of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with IMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0000310molecular_functionxanthine phosphoribosyltransferase activity
A0004422molecular_functionhypoxanthine phosphoribosyltransferase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006178biological_processguanine salvage
A0016757molecular_functionglycosyltransferase activity
A0020015cellular_componentglycosome
A0031981cellular_componentnuclear lumen
A0032263biological_processGMP salvage
A0032264biological_processIMP salvage
A0042301molecular_functionphosphate ion binding
A0046100biological_processhypoxanthine metabolic process
A0046872molecular_functionmetal ion binding
A0052657molecular_functionguanine phosphoribosyltransferase activity
B0000287molecular_functionmagnesium ion binding
B0000310molecular_functionxanthine phosphoribosyltransferase activity
B0004422molecular_functionhypoxanthine phosphoribosyltransferase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006178biological_processguanine salvage
B0016757molecular_functionglycosyltransferase activity
B0020015cellular_componentglycosome
B0031981cellular_componentnuclear lumen
B0032263biological_processGMP salvage
B0032264biological_processIMP salvage
B0042301molecular_functionphosphate ion binding
B0046100biological_processhypoxanthine metabolic process
B0046872molecular_functionmetal ion binding
B0052657molecular_functionguanine phosphoribosyltransferase activity
C0000287molecular_functionmagnesium ion binding
C0000310molecular_functionxanthine phosphoribosyltransferase activity
C0004422molecular_functionhypoxanthine phosphoribosyltransferase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006178biological_processguanine salvage
C0016757molecular_functionglycosyltransferase activity
C0020015cellular_componentglycosome
C0031981cellular_componentnuclear lumen
C0032263biological_processGMP salvage
C0032264biological_processIMP salvage
C0042301molecular_functionphosphate ion binding
C0046100biological_processhypoxanthine metabolic process
C0046872molecular_functionmetal ion binding
C0052657molecular_functionguanine phosphoribosyltransferase activity
D0000287molecular_functionmagnesium ion binding
D0000310molecular_functionxanthine phosphoribosyltransferase activity
D0004422molecular_functionhypoxanthine phosphoribosyltransferase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006178biological_processguanine salvage
D0016757molecular_functionglycosyltransferase activity
D0020015cellular_componentglycosome
D0031981cellular_componentnuclear lumen
D0032263biological_processGMP salvage
D0032264biological_processIMP salvage
D0042301molecular_functionphosphate ion binding
D0046100biological_processhypoxanthine metabolic process
D0046872molecular_functionmetal ion binding
D0052657molecular_functionguanine phosphoribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue IMP A 301
ChainResidue
AGLU147
ATYR201
AVAL202
AILE149
AASP151
ATHR152
AGLY153
AARG154
ATHR155
ALYS180
AARG200

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 302
ChainResidue
ALYS87
AGLY88
AARG214
AHOH401
AHOH402

site_idAC3
Number of Residues14
Detailsbinding site for residue IMP B 3301
ChainResidue
BGLU147
BASP148
BILE149
BALA150
BASP151
BTHR152
BGLY153
BARG154
BTHR155
BLYS180
BTYR201
BVAL202
BPHE207
BHOH3401

site_idAC4
Number of Residues3
Detailsbinding site for residue MG B 3302
ChainResidue
BLYS87
BARG214
BHOH3405

site_idAC5
Number of Residues10
Detailsbinding site for residue IMP C 301
ChainResidue
CGLU147
CILE149
CASP151
CTHR152
CGLY153
CARG154
CTHR155
CLYS180
CTYR201
CVAL202

site_idAC6
Number of Residues2
Detailsbinding site for residue MG C 302
ChainResidue
CLYS87
CARG214

site_idAC7
Number of Residues12
Detailsbinding site for residue IMP D 301
ChainResidue
DILE149
DASP151
DTHR152
DGLY153
DARG154
DTHR155
DLYS180
DARG200
DTYR201
DVAL202
DPHE207
DHOH401

238895

PDB entries from 2025-07-16

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