6MXB

Crystal structure of Trypanosoma brucei hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with XMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Hypoxanthine-guanine phosphoribosyltransferase, putative	polymer	272	30639.0	6	UniProt (Q38CA1) Pfam (PF00156)	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
2	G, J, K, L, N... (A, B, C, D, E...)	XANTHOSINE-5'-MONOPHOSPHATE	non-polymer		365.2	6	Chemie (XMP)
3	H, I, M (A, D)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	P, Q, R, S, T... (A, B, C, D, E...)	water	water		18.0	606	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 2 - 234 (UniProt: Q38CA1)

PDB	External Database	Details
Met -37	-	expression tag
Gly -36	-	expression tag
Ser -35	-	expression tag
Ser -34	-	expression tag
His -33	-	expression tag
His -32	-	expression tag
His -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
Asp -27	-	expression tag
Tyr -26	-	expression tag
Asp -25	-	expression tag
Ile -24	-	expression tag
Pro -23	-	expression tag
Thr -22	-	expression tag
Thr -21	-	expression tag
Glu -20	-	expression tag
Asn -19	-	expression tag
Leu -18	-	expression tag
Tyr -17	-	expression tag
Phe -16	-	expression tag
Gln -15	-	expression tag
Gly -14	-	expression tag
His -13	-	expression tag
Met -12	-	expression tag
Ala -11	-	expression tag
Ser -10	-	expression tag
Met -9	-	expression tag
Thr -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gln -5	-	expression tag
Gln -4	-	expression tag
Met -3	-	expression tag
Gly -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	183834.0
Non-Polymers*	Number of molecules	9
	Total formula weight	2264.2
All*	Total formula weight	186098.2

*Water molecules are not included.