6MWE

CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Angiopoietin-1 receptor	polymer	317	36253.3	2	UniProt (Q02763) Pfam (PF07714)	Homo sapiens (Human)	Endothelial tyrosine kinase,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,hTIE2,p140 TEK
2	C, D, F, G (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	E, H (A, B)	4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide	non-polymer		553.6	2	Chemie (919)
4	I, J (A, B)	water	water		18.0	231	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72506.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1491.4
All*	Total formula weight	73998.1

*Water molecules are not included.