6MVX

NavAb Voltage-gated Sodium Channel, I217C, in Complex with Class 1C Anti-arrhythmic Flecainide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Ion transport protein	polymer	285	33105.1	4	UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016)	Arcobacter butzleri (strain RM4018)
2	E, F, G, I, J... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	10	Chemie (PO4)
3	H (A)	Flecainide	non-polymer		414.3	1	Chemie (K4D)

Sequence modifications

A, B, C, D: 1001 - 1267 (UniProt: A8EVM5)

PDB	External Database	Details
Met 983	-	initiating methionine
Asp 984	-	expression tag
Tyr 985	-	expression tag
Lys 986	-	expression tag
Asp 987	-	expression tag
Asp 988	-	expression tag
Asp 989	-	expression tag
Asp 990	-	expression tag
Lys 991	-	expression tag
Gly 992	-	expression tag
Ser 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Cys 1217	Ile 217	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	132420.4
Non-Polymers*	Number of molecules	11
	Total formula weight	1364.1
All*	Total formula weight	133784.4

*Water molecules are not included.