6MUF
Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.4 Angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Envelope glycoprotein gp160 | polymer | 153 | 17357.8 | 1 | UniProt (B3UEZ6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | D | 35O22 scFv heavy chain portion | polymer | 134 | 14662.3 | 1 | Homo sapiens (Human) | ||
| 3 | E | 35O22 scFv light chain portion | polymer | 114 | 12358.6 | 1 | Homo sapiens (Human) | ||
| 4 | G | Envelope glycoprotein gp160 | polymer | 489 | 54991.2 | 1 | UniProt (B3UES2) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
| 5 | H | 3H109L Fab heavy chain | polymer | 244 | 26255.5 | 1 | Homo sapiens (Human) | ||
| 6 | L | 3H109L Fab light chain | polymer | 217 | 23416.1 | 1 | Homo sapiens | ||
| 7 | A | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 8 | C | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 9 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 10 | I | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 11 | B, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) |
Sequence modifications
B: 512 - 664 (UniProt: B3UEZ6)
G: 31 - 507 (UniProt: B3UES2)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 563 | engineered mutation |
| Cys 605 | Thr 609 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 501 | Ala 505 | conflict |
| Arg 508 | - | expression tag |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Arg 511 | - | expression tag |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 149041.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3967.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2433.3 | |
| All* | Total formula weight | 155442.5 |
