6MSC
Novel, potent, selective and brain penetrant phosphodiesterase 10A inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 332 | 38363.1 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | 8-fluoro-6-methoxy-3-methyl-1-(3-methylpyridin-4-yl)-3H-pyrazolo[3,4-c]cinnoline | non-polymer | 323.3 | 2 | Chemie (JY7) | |||
5 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 776 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Gly 445 | - | expression tag |
Ser 446 | - | expression tag |
His 447 | - | expression tag |
Met 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 76726.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 826.1 | |
All* | Total formula weight | 77552.3 |