6MQL

Crystal Structure of GTPase Domain of Human Septin 12 Mutant T89M

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Septin-12	polymer	295	34126.2	1	UniProt (Q8IYM1) Pfam (PF00735)	Homo sapiens (Human)
2	B (A)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	D (A)	water	water		18.0	45	Chemie (HOH)

Sequence modifications

A: 46 - 320 (UniProt: Q8IYM1)

PDB	External Database	Details
Met 26	-	expression tag
Gly 27	-	expression tag
Ser 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
Ser 36	-	expression tag
Ser 37	-	expression tag
Gly 38	-	expression tag
Leu 39	-	expression tag
Val 40	-	expression tag
Pro 41	-	expression tag
Arg 42	-	expression tag
Gly 43	-	expression tag
Ser 44	-	expression tag
His 45	-	expression tag
Met 89	Thr 89	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34126.2
Non-Polymers*	Number of molecules	2
	Total formula weight	467.5
All*	Total formula weight	34593.7

*Water molecules are not included.