6MQ8

Binary structure of DNA polymerase eta in complex with templating hypoxanthine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA polymerase eta	polymer	439	49211.3	1	UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799)	Homo sapiens (Human)	RAD30 homolog A,Xeroderma pigmentosum variant type protein
2	B (T)	DNA (5'-D(*CP*AP*TP*IP*AP*TP*GP*AP*CP*GP*CP*T)-3')	polymer	12	3647.4	1		synthetic construct
3	C (P)	DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3')	polymer	8	2426.6	1		synthetic construct
4	D (A)	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine	non-polymer		466.2	1	Chemie (0KX)
5	E, F (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	G, H (A, P)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7	I, J, K (A, T, P)	water	water		18.0	365	Chemie (HOH)

Sequence modifications

A: 3 - 432 (UniProt: Q9Y253)

PDB	External Database	Details
Met -6	-	initiating methionine
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55285.3
Non-Polymers*	Number of molecules	5
	Total formula weight	560.8
All*	Total formula weight	55846.1

*Water molecules are not included.