6MOE
Monomeric DARPin E2 complex with EpoR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E2 DARPin | polymer | 168 | 17965.3 | 2 | synthetic construct | ||
| 2 | C, D | Erythropoietin receptor | polymer | 229 | 25129.4 | 2 | UniProt (P19235) Pfam (PF09067) Pfam (PF00041) In PDB | Homo sapiens (Human) | EPO-R |
| 3 | A, B, C, D | PHOSPHATE ION | non-polymer | 95.0 | 9 | Chemie (PO4) | |||
| 4 | A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | B | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | water | water | 18.0 | 448 | Chemie (HOH) |
Sequence modifications
C, D: 8 - 225 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| Phe 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Gln 52 | Asn 76 | conflict |
| Gln 164 | Asn 188 | conflict |
| Lys 226 | - | expression tag |
| Glu 227 | - | expression tag |
| Lys 228 | - | expression tag |
| Ala 229 | - | expression tag |
| Ala 230 | - | expression tag |
| Ala 231 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86189.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1217.2 | |
| All* | Total formula weight | 87406.6 |
