6MOE

Monomeric DARPin E2 complex with EpoR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	E2 DARPin	polymer	168	17965.3	2		synthetic construct
2	C, D (C, D)	Erythropoietin receptor	polymer	229	25129.4	2	UniProt (P19235) Pfam (PF09067) Pfam (PF00041)	Homo sapiens (Human)	EPO-R
3	E, F, H, J, K... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	9	Chemie (PO4)
4	G, M (A, C)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	I (B)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
6	Q, R, S, T (A, B, C, D)	water	water		18.0	448	Chemie (HOH)

Sequence modifications

C, D: 8 - 225 (UniProt: P19235)

PDB	External Database	Details
Phe 3	-	expression tag
Ala 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag
Ala 7	-	expression tag
Gln 52	Asn 76	conflict
Gln 164	Asn 188	conflict
Lys 226	-	expression tag
Glu 227	-	expression tag
Lys 228	-	expression tag
Ala 229	-	expression tag
Ala 230	-	expression tag
Ala 231	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	86189.4
Non-Polymers*	Number of molecules	12
	Total formula weight	1217.2
All*	Total formula weight	87406.6

*Water molecules are not included.