6MO9
N-terminal bromodomain of human BRD2 in complex with N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)quinoline-5-sulfonamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Bromodomain-containing protein 2 | polymer | 126 | 14916.4 | 3 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | D, E, F (A, B) | N-cyclopentyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-5-sulfonamide | non-polymer | 371.5 | 3 | Chemie (JVY) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 251 | Chemie (HOH) |
Sequence modifications
A, B, C: 71 - 194 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 69 | - | expression tag |
| Met 70 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44749.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1114.4 | |
| All* | Total formula weight | 45863.7 |
