6MO9

N-terminal bromodomain of human BRD2 in complex with N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)quinoline-5-sulfonamide inhibitor

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue JVY A 201

Chain	Residue
A	GLN80
A	HOH355
C	PRO98
C	PHE99
C	LEU108
C	ASN156
C	ILE162
C	HOH215

---

site_id	AC2
Number of Residues	13
Details	binding site for residue JVY A 202

Chain	Residue
A	PRO98
A	PHE99
A	LEU108
A	LEU110
A	ASN156
A	ILE162
A	MET165
A	HOH309
A	HOH349
A	HOH372
A	HOH379
B	GLN94
A	TRP97

---

site_id	AC3
Number of Residues	10
Details	binding site for residue JVY B 201

Chain	Residue
A	GLN94
B	TRP97
B	PRO98
B	PHE99
B	LEU108
B	ASN156
B	MET165
B	HOH312
B	HOH339
B	HOH361

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA96-TYR155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---