6MO8
N-terminal bromodomain of human BRD2 in complex with 4,4'-(quinoline-5,7-diyl)bis(3,5-dimethylisoxazole) inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Bromodomain-containing protein 2 | polymer | 126 | 14916.4 | 3 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
2 | A, B | 5,7-bis(3,5-dimethyl-1,2-oxazol-4-yl)quinoline | non-polymer | 319.4 | 3 | Chemie (JWD) | |||
3 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A, B, C: 71 - 194 (UniProt: P25440)
PDB | External Database | Details |
---|---|---|
Ser 69 | - | expression tag |
Met 70 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 44749.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1054.1 | |
All* | Total formula weight | 45803.4 |