6MO8
N-terminal bromodomain of human BRD2 in complex with 4,4'-(quinoline-5,7-diyl)bis(3,5-dimethylisoxazole) inhibitor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue JWD A 201 |
| Chain | Residue |
| A | TRP97 |
| A | PHE99 |
| A | LEU108 |
| A | ASN156 |
| A | HOH318 |
| A | HOH365 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue JWD A 202 |
| Chain | Residue |
| A | HOH338 |
| C | TRP97 |
| C | PRO98 |
| C | PHE99 |
| C | LEU110 |
| C | ASN156 |
| C | HOH216 |
| A | ASN77 |
| A | GLN80 |
| A | LEU187 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | TRP97 |
| B | ARG100 |
| B | HOH346 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH204 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue JWD B 202 |
| Chain | Residue |
| A | GLN94 |
| B | TRP97 |
| B | PHE99 |
| B | ASN156 |
| B | HOH312 |
| B | HOH340 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
