6MN2
Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aminoglycoside N(3)-acetyltransferase | polymer | 263 | 28654.3 | 2 | UniProt (A0A059X981) UniProt (by SIFTS) (A0ACD6B8R8) | uncultured bacterium | |
| 2 | C, I (A, B) | COENZYME A | non-polymer | 767.5 | 2 | Chemie (COA) | |||
| 3 | D, J (A, B) | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside | non-polymer | 447.5 | 2 | Chemie (SIS) PubChem (20849284) PubChem (5224) PubChem (23789067) PubChem (16757732) PubChem (65453) PubChem (51340727) PubChem (52785036) PubChem (68111758) PubChem (155901534) PubChem (3071575) PubChem (36119) PubChem (71752202) PubChem (5284617) PubChem (90657841) PubChem (93472699) PubChem (94865131) PubChem (96367588) PubChem (98047666) PubChem (5702116) PubChem (93472696) PubChem (93472697) PubChem (93472698) PubChem (10095151) PubChem (94865130) PubChem (94865132) PubChem (94865133) PubChem (96367587) PubChem (6604411) PubChem (98047664) PubChem (98047665) PubChem (98047667) PubChem (122197250) PubChem (123134108) PubChem (124708572) PubChem (124708573) PubChem (124708574) PubChem (124708575) PubChem (145797059) PubChem (12942014) PubChem (12942020) PubChem (162995154) PubChem (125463018) PubChem (125463019) PubChem (125463020) PubChem (125463021) PubChem (132062459) PubChem (134694036) PubChem (138969941) PubChem (146158589) PubChem (162995153) PubChem (162995155) PubChem (162995156) PubChem (163285275) PubChem (165339214) PubChem (173721903) PubChem (173871471) | |||
| 4 | E, F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 5 | H, L (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) PubChem (8117) | |||
| 6 | K (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 263 (UniProt: A0A059X981)
| PDB | External Database | Details |
|---|---|---|
| Val 1 | - | expression tag |
| Ala 168 | His 168 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57308.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2844.8 | |
| All* | Total formula weight | 60153.5 |
