6MN2

Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008080	molecular_function	N-acetyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046353	molecular_function	aminoglycoside 3-N-acetyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0008080	molecular_function	N-acetyltransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046353	molecular_function	aminoglycoside 3-N-acetyltransferase activity
B	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL A 303

Chain	Residue
A	ARG78

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site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 305

Chain	Residue
A	ARG8

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site_id	AC3
Number of Residues	2
Details	binding site for residue PEG A 306

Chain	Residue
A	TYR136
A	PHE202

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site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG78
B	HOH407

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site_id	AC5
Number of Residues	1
Details	binding site for residue PEG B 304

Chain	Residue
B	TYR136

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site_id	AC6
Number of Residues	25
Details	binding site for residues COA A 301 and SIS A 302

Chain	Residue
A	ALA31
A	LEU32
A	ARG33
A	PRO42
A	TYR62
A	ASP64
A	ASP69
A	ASN95
A	GLY96
A	PHE97
A	GLY115
A	TYR138
A	PRO160
A	ASP162
A	THR163
A	THR204
A	SER205
A	HOH411
A	HOH423
A	HOH424
A	HOH439
B	GLN66
B	ARG93
A	HIS29
A	ALA30

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site_id	AC7
Number of Residues	23
Details	binding site for residues COA B 301 and SIS B 302

Chain	Residue
A	GLN66
A	ARG93
B	HIS29
B	ALA30
B	LEU32
B	ARG33
B	PRO42
B	TYR62
B	ASP64
B	ASP69
B	ASN95
B	GLY96
B	PHE97
B	GLY115
B	TYR138
B	PRO160
B	ASP162
B	THR163
B	THR165
B	THR204
B	SER205
B	HOH401
B	HOH409

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