6MN2
Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0008080 | molecular_function | N-acetyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0046353 | molecular_function | aminoglycoside 3-N-acetyltransferase activity |
| B | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | ARG78 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 305 |
| Chain | Residue |
| A | ARG8 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 306 |
| Chain | Residue |
| A | TYR136 |
| A | PHE202 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | ARG78 |
| B | HOH407 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue PEG B 304 |
| Chain | Residue |
| B | TYR136 |
| site_id | AC6 |
| Number of Residues | 25 |
| Details | binding site for residues COA A 301 and SIS A 302 |
| Chain | Residue |
| A | ALA31 |
| A | LEU32 |
| A | ARG33 |
| A | PRO42 |
| A | TYR62 |
| A | ASP64 |
| A | ASP69 |
| A | ASN95 |
| A | GLY96 |
| A | PHE97 |
| A | GLY115 |
| A | TYR138 |
| A | PRO160 |
| A | ASP162 |
| A | THR163 |
| A | THR204 |
| A | SER205 |
| A | HOH411 |
| A | HOH423 |
| A | HOH424 |
| A | HOH439 |
| B | GLN66 |
| B | ARG93 |
| A | HIS29 |
| A | ALA30 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residues COA B 301 and SIS B 302 |
| Chain | Residue |
| A | GLN66 |
| A | ARG93 |
| B | HIS29 |
| B | ALA30 |
| B | LEU32 |
| B | ARG33 |
| B | PRO42 |
| B | TYR62 |
| B | ASP64 |
| B | ASP69 |
| B | ASN95 |
| B | GLY96 |
| B | PHE97 |
| B | GLY115 |
| B | TYR138 |
| B | PRO160 |
| B | ASP162 |
| B | THR163 |
| B | THR165 |
| B | THR204 |
| B | SER205 |
| B | HOH401 |
| B | HOH409 |
