6MMV
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Glutamate receptor ionotropic, NMDA 1 | polymer | 797 | 89853.7 | 2 | UniProt (P35439) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
2 | B | Glutamate receptor ionotropic, NMDA 2A | polymer | 800 | 89580.5 | 1 | UniProt (Q00959) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A |
3 | D | Glutamate receptor ionotropic, NMDA 2A | polymer | 800 | 89543.5 | 1 | UniProt (Q00959) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A |
4 | E, F, G, H, I... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
5 | C, D, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 26 | Chemie (NAG) |
Sequence modifications
B: 1 - 800 (UniProt: Q00959)
D: 1 - 800 (UniProt: Q00959)
PDB | External Database | Details |
---|---|---|
Thr 758 | Ser 758 | conflict |
PDB | External Database | Details |
---|---|---|
Ser 128 | His 128 | engineered mutation |
Gln 687 | Asn 687 | engineered mutation |
Thr 758 | Ser 758 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 358831.3 | |
Branched | Number of molecules | 6 |
Total formula weight | 2546.4 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 5751.4 | |
All* | Total formula weight | 367129.1 |