6MMV
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
A | 0016020 | cellular_component | membrane |
A | 0038023 | molecular_function | signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
B | 0016020 | cellular_component | membrane |
B | 0038023 | molecular_function | signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
C | 0016020 | cellular_component | membrane |
C | 0038023 | molecular_function | signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
D | 0016020 | cellular_component | membrane |
D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 532 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
D | GLN23-ALA555 | |
C | ARG19-GLN559 |
site_id | SWS_FT_FI2 |
Number of Residues | 39 |
Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:B7ZSK1 |
Chain | Residue | Details |
D | SER556-PHE576 | |
D | THR626-TYR645 | |
C | SER560-LEU580 | |
C | ILE631-TYR647 |
site_id | SWS_FT_FI3 |
Number of Residues | 27 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
D | GLU577-THR600 | |
D | ASN621-THR625 | |
C | ASP581-THR602 | |
C | ARG625-ARG630 |
site_id | SWS_FT_FI4 |
Number of Residues | 19 |
Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:B7ZSK1 |
Chain | Residue | Details |
D | ILE601-GLN620 | |
C | LEU603-PRO624 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27916457, ECO:0007744|PDB:5TPW |
Chain | Residue | Details |
D | HIS44 | |
D | SER128 | |
D | GLU266 | |
D | ASP282 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
Chain | Residue | Details |
D | SER511 | |
A | SER688 | |
A | ASP732 | |
C | ARG523 | |
C | SER688 | |
C | ASP732 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
Chain | Residue | Details |
D | ARG518 | |
A | ASN239 | |
C | ASN61 | |
C | ASN239 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 |
Chain | Residue | Details |
D | SER689 | |
D | TYR730 | |
C | ASN203 | |
C | ASN368 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
Chain | Residue | Details |
D | ASN614 | |
C | ASN276 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
D | ASN75 | |
D | ASN340 | |
D | ASN443 | |
D | ASN444 | |
D | ASN541 | |
D | GLN687 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084 |
Chain | Residue | Details |
A | ASN350 | |
A | ASN771 | |
C | ASN350 | |
C | ASN771 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5, ECO:0007744|PubMed:24090084 |
Chain | Residue | Details |
A | ASN440 | |
C | ASN440 |
site_id | SWS_FT_FI13 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN471 | |
A | ASN491 | |
A | ASN674 | |
C | ASN471 | |
C | ASN491 | |
C | ASN674 |