6MM8
Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 K2879A, S2813D phosphomimetic (2699-2904) crystal form 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 339 | 39598.2 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus (Mouse) | PKA C-alpha |
| 2 | B (D) | Ryanodine receptor 2 | polymer | 209 | 24285.6 | 1 | UniProt (E9Q401) Pfam (PF02026) | Mus musculus (Mouse) | RyR2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor |
| 3 | C (C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | D, J (C, D) | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
| 5 | E (C) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 6 | F, G, H, I, K (C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | L (D) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | M, N (C, D) | water | water | 18.0 | 503 | Chemie (HOH) |
Sequence modifications
C: 15 - 350 (UniProt: P05132)
D: 2699 - 2904 (UniProt: E9Q401)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | - | expression tag |
| Asn 13 | - | expression tag |
| Ala 14 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 2696 | - | expression tag |
| Asn 2697 | - | expression tag |
| Ala 2698 | - | expression tag |
| Asp 2813 | Ser 2813 | engineered mutation |
| Ala 2879 | Lys 2879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63883.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1078.2 | |
| All* | Total formula weight | 64962.0 |
