6MGU

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus Anthracis in the complex with inhibitor Oxanosine monophosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Inosine-5'-monophosphate dehydrogenase	polymer	363	38237.9	2	UniProt (A0A0J1HJU0) Pfam (PF00478) UniProt (by SIFTS) (A0A6L8P2U9)	Bacillus anthracis	IMPDH
2	C, I (A, B)	5-[(Z)-(aminomethylidene)amino]-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid	non-polymer		366.2	2	Chemie (JQS)
3	D, J (A, B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
4	E, K (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	F (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
6	G, H, L, M (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
7	N, O (A, B)	water	water		18.0	236	Chemie (HOH)

Sequence modifications

A, B: 1 - 91 (UniProt: A0A0J1HJU0)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A, B: 221 - 487 (UniProt: A0A0J1HJU0)

PDB	External Database	Details
Gly 92	-	linker
Gly 220	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76475.8
Non-Polymers*	Number of molecules	11
	Total formula weight	1509.4
All*	Total formula weight	77985.2

*Water molecules are not included.