6MGQ
ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Endoplasmic reticulum aminopeptidase 1 | polymer | 948 | 108557.3 | 3 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | D, E, F (D, E, F) | Phosphinic inhibitor DG014 | polymer | 10 | 1280.4 | 3 | BIRD (PRD_002326) | synthetic construct | |
| 3 | G (G) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 4 | H, K, L (H, K, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | I, J (I, J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 6 | M, O, Q (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 7 | N, P, R (A, B, C) | UNKNOWN ATOM OR ION | non-polymer | 18.0 | 3 | Chemie (UNX) | |||
| 8 | S, T, U (A, B, C) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B, C: 33 - 948 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| Asp 346 | Gly 346 | conflict |
| Arg 514 | Gly 514 | conflict |
| Arg 528 | Lys 528 | conflict |
| Glu 730 | Gln 730 | conflict |
| Leu 949 | - | expression tag |
| Glu 950 | - | expression tag |
| Arg 951 | - | expression tag |
| Met 952 | - | expression tag |
| Leu 953 | - | expression tag |
| Glu 954 | - | expression tag |
| Ser 955 | - | expression tag |
| Arg 956 | - | expression tag |
| Gly 957 | - | expression tag |
| Pro 958 | - | expression tag |
| Phe 959 | - | expression tag |
| Glu 960 | - | expression tag |
| Gln 961 | - | expression tag |
| Lys 962 | - | expression tag |
| Leu 963 | - | expression tag |
| Ile 964 | - | expression tag |
| Ser 965 | - | expression tag |
| Glu 966 | - | expression tag |
| Glu 967 | - | expression tag |
| Asp 968 | - | expression tag |
| Leu 969 | - | expression tag |
| Asn 970 | - | expression tag |
| Met 971 | - | expression tag |
| His 972 | - | expression tag |
| Thr 973 | - | expression tag |
| Glu 974 | - | expression tag |
| His 975 | - | expression tag |
| His 976 | - | expression tag |
| His 977 | - | expression tag |
| His 978 | - | expression tag |
| His 979 | - | expression tag |
| His 980 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 329513.1 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3195.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 250.3 | |
| All* | Total formula weight | 332958.4 |
