6MGQ
ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Endoplasmic reticulum aminopeptidase 1 | polymer | 948 | 108557.3 | 3 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | Homo sapiens (Human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
2 | D, E, F | Phosphinic inhibitor DG014 | polymer | 10 | 1280.4 | 3 | BIRD (PRD_002326) | synthetic construct | |
3 | G | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
4 | H, K, L | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
5 | I, J | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
6 | A, B, C | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
7 | A, B, C | UNKNOWN ATOM OR ION | non-polymer | 18.0 | 3 | Chemie (UNX) | |||
8 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B, C: 33 - 948 (UniProt: Q9NZ08)
PDB | External Database | Details |
---|---|---|
Asp 346 | Gly 346 | conflict |
Arg 514 | Gly 514 | conflict |
Arg 528 | Lys 528 | conflict |
Glu 730 | Gln 730 | conflict |
Leu 949 | - | expression tag |
Glu 950 | - | expression tag |
Arg 951 | - | expression tag |
Met 952 | - | expression tag |
Leu 953 | - | expression tag |
Glu 954 | - | expression tag |
Ser 955 | - | expression tag |
Arg 956 | - | expression tag |
Gly 957 | - | expression tag |
Pro 958 | - | expression tag |
Phe 959 | - | expression tag |
Glu 960 | - | expression tag |
Gln 961 | - | expression tag |
Lys 962 | - | expression tag |
Leu 963 | - | expression tag |
Ile 964 | - | expression tag |
Ser 965 | - | expression tag |
Glu 966 | - | expression tag |
Glu 967 | - | expression tag |
Asp 968 | - | expression tag |
Leu 969 | - | expression tag |
Asn 970 | - | expression tag |
Met 971 | - | expression tag |
His 972 | - | expression tag |
Thr 973 | - | expression tag |
Glu 974 | - | expression tag |
His 975 | - | expression tag |
His 976 | - | expression tag |
His 977 | - | expression tag |
His 978 | - | expression tag |
His 979 | - | expression tag |
His 980 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 329513.1 | |
Branched | Number of molecules | 6 |
Total formula weight | 3195.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 250.3 | |
All* | Total formula weight | 332958.4 |