Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MGQ

ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0002250	biological_process	adaptive immune response
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0004175	molecular_function	endopeptidase activity
A	0004177	molecular_function	aminopeptidase activity
A	0005138	molecular_function	interleukin-6 receptor binding
A	0005151	molecular_function	interleukin-1, type II receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006509	biological_process	membrane protein ectodomain proteolysis
A	0008217	biological_process	regulation of blood pressure
A	0008233	molecular_function	peptidase activity
A	0008235	molecular_function	metalloexopeptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0009617	biological_process	response to bacterium
A	0016020	cellular_component	membrane
A	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
A	0042277	molecular_function	peptide binding
A	0043171	biological_process	peptide catabolic process
A	0045088	biological_process	regulation of innate immune response
A	0045444	biological_process	fat cell differentiation
A	0045766	biological_process	positive regulation of angiogenesis
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
A	0070062	cellular_component	extracellular exosome
B	0001525	biological_process	angiogenesis
B	0002250	biological_process	adaptive immune response
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0004175	molecular_function	endopeptidase activity
B	0004177	molecular_function	aminopeptidase activity
B	0005138	molecular_function	interleukin-6 receptor binding
B	0005151	molecular_function	interleukin-1, type II receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006509	biological_process	membrane protein ectodomain proteolysis
B	0008217	biological_process	regulation of blood pressure
B	0008233	molecular_function	peptidase activity
B	0008235	molecular_function	metalloexopeptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0009617	biological_process	response to bacterium
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0042277	molecular_function	peptide binding
B	0043171	biological_process	peptide catabolic process
B	0045088	biological_process	regulation of innate immune response
B	0045444	biological_process	fat cell differentiation
B	0045766	biological_process	positive regulation of angiogenesis
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
B	0070062	cellular_component	extracellular exosome
C	0001525	biological_process	angiogenesis
C	0002250	biological_process	adaptive immune response
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0004175	molecular_function	endopeptidase activity
C	0004177	molecular_function	aminopeptidase activity
C	0005138	molecular_function	interleukin-6 receptor binding
C	0005151	molecular_function	interleukin-1, type II receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0006509	biological_process	membrane protein ectodomain proteolysis
C	0008217	biological_process	regulation of blood pressure
C	0008233	molecular_function	peptidase activity
C	0008235	molecular_function	metalloexopeptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0009617	biological_process	response to bacterium
C	0016020	cellular_component	membrane
C	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
C	0042277	molecular_function	peptide binding
C	0043171	biological_process	peptide catabolic process
C	0045088	biological_process	regulation of innate immune response
C	0045444	biological_process	fat cell differentiation
C	0045766	biological_process	positive regulation of angiogenesis
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
C	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHELAHQW

Chain	Residue	Details
A	THR350-TRP359

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU354
B	GLU354
C	GLU354

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU183
A	GLY317
B	GLU183
B	GLY317
C	GLU183
C	GLY317

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING:

Chain	Residue	Details
B	HIS353
B	HIS357
B	GLU376
C	HIS353
C	HIS357
C	GLU376
A	HIS353
A	HIS357
A	GLU376

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	TYR438
B	TYR438
C	TYR438

site_id	SWS_FT_FI5
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:21478864, ECO:0000269\|Ref.16

Chain	Residue	Details
A	ASN70
A	ASN154
B	ASN70
B	ASN154
C	ASN70
C	ASN154

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|Ref.16

Chain	Residue	Details
A	ASN414
B	ASN414
C	ASN414

site_id	SWS_FT_FI7
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:21478864

Chain	Residue	Details
A	ASN760
B	ASN760
C	ASN760

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN901
B	ASN901
C	ASN901

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)