6MEI

Crystal structure of broadly neutralizing antibody HEPC3 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	E2 glycoprotein	polymer	270	29945.6	1	UniProt (A0A2P0NE26) Pfam (PF01560)	Hepacivirus C
2	B (H)	antibody HEPC3 Heavy Chain	polymer	241	25759.8	1		Homo sapiens
3	C (L)	antibody HEPC3 Light Chain	polymer	214	23384.9	1		Homo sapiens
4	D (A)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E, F (B, D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6	G, H, I, J, K (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	L, M, N, O, P... (C, H, L)	BROMIDE ION	non-polymer		79.9	7	Chemie (BR)
8	S, T, U (C, H, L)	water	water		18.0	204	Chemie (HOH)

Sequence modifications

C: 384 - 645 (UniProt: A0A2P0NE26)

PDB	External Database	Details
Ile 646	-	expression tag
Gly 647	-	expression tag
His 648	-	expression tag
His 649	-	expression tag
His 650	-	expression tag
His 651	-	expression tag
His 652	-	expression tag
His 653	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	79090.2
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1665.4
All*	Total formula weight	82353.1

*Water molecules are not included.