6ME8
XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin | polymer | 460 | 51515.6 | 2 | UniProt (P0ABE7) UniProt (P49286) UniProt (P00268) Pfam (PF07361) Pfam (PF00001) Pfam (PF00301) | Escherichia coli | Cytochrome b-562,Mel1b receptor,Rd,Mel1b receptor |
| 2 | C, E (A, B) | N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide | non-polymer | 308.4 | 2 | Chemie (JEY) | |||
| 3 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A, B: 2001 - 2106 (UniProt: P0ABE7)
A, B: 35 - 231 (UniProt: P49286)
A, B: 1000 - 1052 (UniProt: P00268)
A, B: 241 - 340 (UniProt: P49286)
| PDB | External Database | Details |
|---|---|---|
| Trp 2007 | Met 29 | engineered mutation |
| Ile 2102 | His 124 | engineered mutation |
| Leu 2106 | Arg 128 | engineered mutation |
| Gly 31 | - | linker |
| Asp 32 | - | linker |
| Gly 33 | - | linker |
| Ala 34 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 37 | Pro 37 | engineered mutation |
| Phe 108 | Leu 108 | engineered mutation |
| Trp 129 | Phe 129 | engineered mutation |
| Asp 137 | Asn 137 | engineered mutation |
| Leu 140 | Cys 140 | engineered mutation |
A, B: 241 - 340 (UniProt: P49286)
| PDB | External Database | Details |
|---|---|---|
| Phe 264 | Trp 264 | engineered mutation |
| Pro 305 | Ala 305 | engineered mutation |
| Asp 312 | Asn 312 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103031.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 682.2 | |
| All* | Total formula weight | 103713.3 |
