6ME8

XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008502	molecular_function	melatonin receptor activity
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0043448	biological_process	alkane catabolic process
A	0046872	molecular_function	metal ion binding
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005506	molecular_function	iron ion binding
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008502	molecular_function	melatonin receptor activity
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain
B	0042597	cellular_component	periplasmic space
B	0043448	biological_process	alkane catabolic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue JEY A 2201

Chain	Residue
A	ALA117
A	ASN268
A	TYR294
A	ALA297
A	TYR298
A	MET120
A	GLY121
A	VAL124
A	ASN175
A	PHE192
A	GLN194
A	TYR200
A	LEU267

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2202

Chain	Residue
A	CYS1005
A	CYS1008
A	CYS1038
A	CYS1041

---

site_id	AC3
Number of Residues	13
Details	binding site for residue JEY B 2201

Chain	Residue
B	ALA117
B	MET120
B	GLY121
B	VAL124
B	ASN175
B	PHE192
B	GLN194
B	TYR200
B	LEU267
B	ASN268
B	TYR294
B	ALA297
B	TYR298

---

Functional Information from PROSITE/UniProt

site_id	PS00202
Number of Residues	11
Details	RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG

Chain	Residue	Details
A	ILE1032-GLY1042

---

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSVwNITAIAIDRYLyI

Chain	Residue	Details
A	GLY126-ILE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP2007
A	ILE2102
B	TRP2007
B	ILE2102

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	LEU43-LEU63
B	LEU43-LEU63

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	SER64-ASN76
A	ASP137-TRP155
B	SER64-ASN76
B	ASP137-TRP155

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	LEU77-ILE97
B	LEU77-ILE97

---

site_id	SWS_FT_FI5
Number of Residues	104
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	LEU98-ALA115
A	PHE177-TYR200
A	ALA275-GLU287
B	LEU98-ALA115
B	PHE177-TYR200
B	ALA275-GLU287

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	SER116-ILE136
B	SER116-ILE136

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	HIS156-PHE176
B	HIS156-PHE176

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	THR201-LEU221
B	THR201-LEU221

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	PHE254-VAL274
B	PHE254-VAL274

---

site_id	SWS_FT_FI10
Number of Residues	40
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	GLY288-TYR308
B	GLY288-TYR308

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:31019305, ECO:0007744|PDB:6ME6

Chain	Residue	Details
A	ASN175
A	GLN194
B	ASN175
B	GLN194

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292

Chain	Residue	Details
A	CYS1005
A	CYS1008
A	CYS1038
A	CYS1041
B	CYS1005
B	CYS1008
B	CYS1038
B	CYS1041

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N-formylmethionine => ECO:0000269|PubMed:1637309

Chain	Residue	Details
A	MET1000
B	MET1000

---