6MDZ
Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protein argonaute-2 | polymer | 859 | 97358.2 | 2 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) In PDB | Homo sapiens (Human) | hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
| 2 | C, D | RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3') | polymer | 21 | 6788.0 | 2 | Homo sapiens | ||
| 3 | E, F | RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*CP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') | polymer | 23 | 7218.4 | 2 | unidentified | ||
| 4 | A, B | PHENOL | non-polymer | 94.1 | 4 | Chemie (IPH) |
Sequence modifications
A, B: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Asp 387 | Ser 387 | engineered mutation |
| Ala 669 | Asp 669 | engineered mutation |
| Ala 824 | Ser 824 | engineered mutation |
| Asp 828 | Ser 828 | engineered mutation |
| Asp 831 | Ser 831 | engineered mutation |
| Ala 834 | Ser 834 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 222729.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 376.4 | |
| All* | Total formula weight | 223105.7 |
