6MCO
Crystal structure of the B41 SOSIP.664 Env trimer with PGT124 and 35O22 Fabs, in P23 space group
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Transmembrane protein gp41 | polymer | 153 | 17373.9 | 1 | UniProt (B3UF08) Pfam (PF00517) UniProt (by SIFTS) (B3UES2) In PDB | Human immunodeficiency virus 1 | TM |
| 2 | D | 35O22 Fab heavy chain | polymer | 243 | 26171.5 | 1 | Homo sapiens (Human) | SU, Glycoprotein 120, gp120 | |
| 3 | E | 35O22 Fab light chain | polymer | 216 | 23318.8 | 1 | Homo sapiens (Human) | ||
| 4 | G | Surface protein gp120 | polymer | 482 | 53977.0 | 1 | UniProt (B3UES2) Pfam (PF00516) UniProt (by SIFTS) (B3UF58) In PDB | Human immunodeficiency virus 1 | |
| 5 | H | PGT124 Fab heavy chain | polymer | 236 | 25460.5 | 1 | Homo sapiens (Human) | ||
| 6 | L | PGT124 Fab light chain | polymer | 214 | 23056.6 | 1 | Homo sapiens (Human) | ||
| 7 | A | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 8 | C, I, Q | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 9 | F | alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G60966ZH) | |||
| 10 | J, M | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 11 | K, N, O, U | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 12 | P | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 13 | R | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 14 | S | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 15 | T | beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G44266EX) | |||
| 16 | G, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
B: 512 - 664 (UniProt: B3UF08)
G: 32 - 507 (UniProt: B3UES2)
| PDB | External Database | Details |
|---|---|---|
| Cys 605 | Thr 609 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 501 | Ala 505 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169358.3 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 11068.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 182196.0 |
