6M4U
Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, E) | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 110 | 12111.8 | 2 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (Human) | PPIase FKBP1A,12 kDa FK506-binding protein,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
| 2 | B, D (B, F) | Serine/threonine-protein kinase mTOR | polymer | 95 | 11447.1 | 2 | UniProt (P42345) Pfam (PF08771) | Homo sapiens (Human) | Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin |
| 3 | E, R (A, E) | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 2 | Chemie (RAP) | |||
| 4 | AA, F, G, H, K... (F, A, B, E) | ZINC ION | non-polymer | 65.4 | 14 | Chemie (ZN) | |||
| 5 | BA, I, J, P, Q... (F, A, B, E) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 6 | X (F) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | CA, DA, EA, FA (A, B, E, F) | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, E: 1 - 108 (UniProt: P62942)
B, F: 2021 - 2113 (UniProt: P42345)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 2019 | - | expression tag |
| Ser 2020 | - | expression tag |
| Leu 2098 | Thr 2098 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47117.9 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3084.3 | |
| All* | Total formula weight | 50202.2 |
