6M06

Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Platelet-activating factor acetylhydrolase	polymer	371	42267.1	2	UniProt (Q13093) Pfam (PF03403) In PDB	Homo sapiens (Human)	PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2,gVIIA-PLA2,LDL-associated phospholipase A2,LDL-PLA(2),PAF 2-acylhydrolase
2	A, B	(2S)-2-[(Z)-1,3-bis(oxidanyl)-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid	non-polymer		201.2	2	Chemie (BWF)
3		water	water		18.0	172	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84534.1
Non-Polymers*	Number of molecules	2
	Total formula weight	402.4
All*	Total formula weight	84936.5

*Water molecules are not included.