6LZ9
t8E4 antibody Fab complexed with the active form of HGF
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor | polymer | 108 | 12280.6 | 1 | UniProt (P14210) Pfam (PF00051) In PDB | Homo sapiens (Human) | Hepatopoietin-A,Scatter factor,SF |
2 | B | Hepatocyte growth factor | polymer | 242 | 27107.4 | 1 | UniProt (P14210) Pfam (PF00089) In PDB | Homo sapiens (Human) | Hepatopoietin-A,Scatter factor,SF |
3 | H | Heavy chain of t8E4 Fab fragment | polymer | 223 | 24075.0 | 1 | Mus musculus | ||
4 | L | Light chain of t8E4 Fab fragment | polymer | 214 | 23847.2 | 1 | Mus musculus | ||
5 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 388 - 494 (UniProt: P14210)
B: 495 - 728 (UniProt: P14210)
PDB | External Database | Details |
---|---|---|
Ser 387 | - | expression tag |
Gln 402 | Asn 402 | engineered mutation |
Gly 476 | Thr 476 | engineered mutation |
Ile 491 | Lys 491 | engineered mutation |
Glu 492 | Gln 492 | engineered mutation |
Gly 493 | Leu 493 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 561 | Cys 561 | engineered mutation |
Gln 566 | Asn 566 | engineered mutation |
Gln 653 | Asn 653 | engineered mutation |
Arg 729 | - | expression tag |
Leu 730 | - | expression tag |
Glu 731 | - | expression tag |
Asn 732 | - | expression tag |
Leu 733 | - | expression tag |
Tyr 734 | - | expression tag |
Phe 735 | - | expression tag |
Gln 736 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 87310.2 | |
All* | Total formula weight | 87310.2 |