6LSH

Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6M form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Genome polyprotein	polymer	468	53408.5	1	UniProt (E5RPG3) Pfam (PF00680) In PDB	Human enterovirus 71 (EV71)
2	B	RNA (35-MER)	polymer	34	10915.5	1		synthetic construct
3	C	RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3')	polymer	18	5811.5	1		synthetic construct
4	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6		water	water		18.0	103	Chemie (HOH)

Sequence modifications

A: 1 - 462 (UniProt: E5RPG3)

PDB	External Database	Details
Ser 114	Thr 1845	engineered mutation
Thr 115	Ser 1846	engineered mutation
Met 291	Cys 2022	engineered mutation
His 463	-	expression tag
His 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	70135.5
Non-Polymers*	Number of molecules	2
	Total formula weight	161.5
All*	Total formula weight	70297.0

*Water molecules are not included.