6LSH
Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6M form)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Genome polyprotein | polymer | 468 | 53408.5 | 1 | UniProt (E5RPG3) Pfam (PF00680) | Human enterovirus 71 (EV71) | |
| 2 | B (B) | RNA (35-MER) | polymer | 34 | 10915.5 | 1 | synthetic construct | ||
| 3 | C (C) | RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3') | polymer | 18 | 5811.5 | 1 | synthetic construct | ||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 1 - 462 (UniProt: E5RPG3)
| PDB | External Database | Details |
|---|---|---|
| Ser 114 | Thr 1845 | engineered mutation |
| Thr 115 | Ser 1846 | engineered mutation |
| Met 291 | Cys 2022 | engineered mutation |
| His 463 | - | expression tag |
| His 464 | - | expression tag |
| His 465 | - | expression tag |
| His 466 | - | expression tag |
| His 467 | - | expression tag |
| His 468 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70135.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 161.5 | |
| All* | Total formula weight | 70297.0 |
