6LSF

Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Genome polyprotein	polymer	468	53408.5	1	UniProt (E5RPG3) Pfam (PF00680) In PDB	Human enterovirus 71 (EV71)
2	B	RNA (35-MER)	polymer	35	11260.7	1		synthetic construct
3	C	RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3')	polymer	18	5811.5	1		synthetic construct
4	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6		water	water		18.0	92	Chemie (HOH)

Sequence modifications

A: 1 - 462 (UniProt: E5RPG3)

PDB	External Database	Details
Met 291	Cys 2022	engineered mutation
His 463	-	expression tag
His 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	70480.7
Non-Polymers*	Number of molecules	2
	Total formula weight	161.5
All*	Total formula weight	70642.2

*Water molecules are not included.