6LSE

Crystal structure of the enterovirus 71 polymerase elongation complex (C3S6A/C3S6B form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Genome polyprotein	polymer	468	53408.5	1	UniProt (E5RPG3) Pfam (PF00680)	Human enterovirus 71 (EV71)
2	B (B)	RNA (35-MER)	polymer	35	11260.7	1		synthetic construct
3	C (C)	RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*CP*U)-3')	polymer	19	6117.7	1		synthetic construct
4	D (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	E, F (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	G (C)	PYROPHOSPHATE 2-	non-polymer		176.0	1	Chemie (POP)
7	H, I, J (A, B, C)	water	water		18.0	171	Chemie (HOH)

Sequence modifications

A: 1 - 462 (UniProt: E5RPG3)

PDB	External Database	Details
Met 291	Cys 2022	engineered mutation
His 463	-	expression tag
His 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	70786.9
Non-Polymers*	Number of molecules	4
	Total formula weight	433.5
All*	Total formula weight	71220.4

*Water molecules are not included.