6LRC
Human cGAS catalytic domain bound with the inhibitor PF-06928215
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | Cyclic GMP-AMP synthase | polymer | 366 | 42759.3 | 2 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) In PDB | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B, A | (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid | non-polymer | 380.4 | 2 | Chemie (KHM) | |||
| 3 | B, A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85518.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 891.6 | |
| All* | Total formula weight | 86410.2 |
