6LPF

The crystal structure of human cytoplasmic LRS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Leucine--tRNA ligase, cytoplasmic	polymer	1092	125188.7	2	UniProt (Q9P2J5) Pfam (PF00133) Pfam (PF08264)	Homo sapiens (Human)	Leucyl-tRNA synthetase,LeuRS
2	C, D (A, B)	5'-O-(L-leucylsulfamoyl)adenosine	non-polymer		459.5	2	Chemie (LSS)
3	E (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	F (B)	2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE	non-polymer		365.4	1	Chemie (VRT)
5	G, H (A, B)	water	water		18.0	682	Chemie (HOH)

Sequence modifications

A, B: 1 - 1070 (UniProt: Q9P2J5)

PDB	External Database	Details
Met -21	-	expression tag
Gly -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
His -6	-	expression tag
Ile -5	-	expression tag
Glu -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	250377.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1376.4
All*	Total formula weight	251753.9

*Water molecules are not included.