6LMK
Cryo-EM structure of the human glucagon receptor in complex with Gs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
| 4 | N | Nb35 | polymer | 138 | 15140.7 | 1 | Lama glama | ||
| 5 | R | Glucagon receptor | polymer | 422 | 48398.1 | 1 | UniProt (P47871) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (Human) | GL-R |
| 6 | E | Glucagon | polymer | 29 | 3486.8 | 1 | UniProt (P01275) Pfam (PF00123) In PDB | Homo sapiens |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: 27 - 432 (UniProt: P47871)
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | conflict |
| Ala 226 | Gly 226 | conflict |
| Ala 268 | Glu 268 | conflict |
| Lys 271 | Asn 271 | conflict |
| Asp 274 | Lys 274 | conflict |
| Lys 280 | Arg 280 | conflict |
| Asp 284 | Thr 284 | conflict |
| Thr 285 | Ile 285 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 433 | - | expression tag |
| Ser 434 | - | expression tag |
| Gly 435 | - | expression tag |
| Ser 436 | - | expression tag |
| Glu 437 | - | expression tag |
| Asp 438 | - | expression tag |
| Gln 439 | - | expression tag |
| Val 440 | - | expression tag |
| Asp 441 | - | expression tag |
| Pro 442 | - | expression tag |
| Arg 443 | - | expression tag |
| Leu 444 | - | expression tag |
| Ile 445 | - | expression tag |
| Asp 446 | - | expression tag |
| Gly 447 | - | expression tag |
| Lys 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 159314.6 | |
| All* | Total formula weight | 159314.6 |
