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6LKE

in meso full-length rat KMO in complex with an inhibitor identified via DNA-encoded chemical library screening

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BKynurenine 3-monooxygenasepolymer49556419.22UniProt (O88867)
Pfam (PF01494)
In PDB
Rattus norvegicus (Rat)Kynurenine 3-hydroxylase
2A, BFLAVIN-ADENINE DINUCLEOTIDEnon-polymer785.52Chemie (FAD)
3A, BSULFATE IONnon-polymer96.12Chemie (SO4)
4A, BCHLORIDE IONnon-polymer35.52Chemie (CL)
5A, B4-chloranyl-2-[[5-chloranyl-2-(5-methoxy-1,3-dihydroisoindol-2-yl)-1,3-thiazol-4-yl]carbonyl-methyl-amino]-5-fluoranyl-benzoic acidnon-polymer496.32Chemie (EGU)
6waterwater18.06Chemie (HOH)
Sequence modifications
A, B: 1 - 478 (UniProt: O88867)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
Glu 479-expression tag
Asn 480-expression tag
Leu 481-expression tag
Tyr 482-expression tag
Phe 483-expression tag
Gln 484-expression tag
Gly 485-expression tag
Asp 486-expression tag
Tyr 487-expression tag
Lys 488-expression tag
Asp 489-expression tag
Asp 490-expression tag
Asp 491-expression tag
Asp 492-expression tag
Lys 493-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight112838.5
Non-Polymers*Number of molecules8
Total formula weight2826.8
All*Total formula weight115665.3
*Water molecules are not included.

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PDB entries from 2024-07-24

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