6LFO
Cryo-EM structure of a class A GPCR monomer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 353 | 40283.8 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38045.6 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | D | Interleukin-8 | polymer | 65 | 7600.9 | 1 | UniProt (P10145) Pfam (PF00048) In PDB | Homo sapiens (Human) | IL-8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,GCP-1,Monocyte-derived neutrophil chemotactic factor,MDNCF,Monocyte-derived neutrophil-activating peptide,MONAP,Neutrophil-activating protein 1,NAP-1,Protein 3-10C,T-cell chemotactic factor |
5 | R | C-X-C chemokine receptor type 2 | polymer | 360 | 40798.1 | 1 | UniProt (P25025) Pfam (PF00001) In PDB | Homo sapiens (Human) | CXCR-2,CDw128b,GRO/MGSA receptor,High affinity interleukin-8 receptor B,IL-8R B,IL-8 receptor type 2 |
6 | S | scFv16 | polymer | 259 | 27784.9 | 1 | Homo sapiens | ||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Ile -5 | - | expression tag |
Gly -4 | - | expression tag |
Arg -3 | - | expression tag |
Ala -2 | - | expression tag |
Arg -1 | - | expression tag |
Gly 0 | - | expression tag |
Phe 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 162374.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 386.7 | |
All* | Total formula weight | 162761.2 |