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6LFO

Cryo-EM structure of a class A GPCR monomer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0072678biological_processT cell migration
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
D0005576cellular_componentextracellular region
D0006935biological_processchemotaxis
D0006952biological_processdefense response
D0006955biological_processimmune response
D0008009molecular_functionchemokine activity
R0002407biological_processdendritic cell chemotaxis
R0004918molecular_functioninterleukin-8 receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005654cellular_componentnucleoplasm
R0005886cellular_componentplasma membrane
R0006935biological_processchemotaxis
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0006968biological_processcellular defense response
R0007165biological_processsignal transduction
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0008284biological_processpositive regulation of cell population proliferation
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0015630cellular_componentmicrotubule cytoskeleton
R0016020cellular_componentmembrane
R0016493molecular_functionC-C chemokine receptor activity
R0016494molecular_functionC-X-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019957molecular_functionC-C chemokine binding
R0019959molecular_functioninterleukin-8 binding
R0030593biological_processneutrophil chemotaxis
R0030667cellular_componentsecretory granule membrane
R0031623biological_processreceptor internalization
R0038112biological_processinterleukin-8-mediated signaling pathway
R0042119biological_processneutrophil activation
R0042629cellular_componentmast cell granule
R0070098biological_processchemokine-mediated signaling pathway
R0072686cellular_componentmitotic spindle
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue CLR R 401
ChainResidue
RASN89
RLEU96
RLEU167

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIlLLACISVDRYLaI
ChainResidueDetails
RSER132-ILE148

site_idPS00471
Number of Residues46
DetailsSMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGphCantEIIvklsdgrel.CLD
ChainResidueDetails
DCYS7-ASP52

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues105
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RMET1-LYS48
RALA106-LYS120
RARG184-ARG208
RASP274-ARG294

site_idSWS_FT_FI2
Number of Residues26
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RTYR49-TYR75
ATHR181

site_idSWS_FT_FI3
Number of Residues91
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RSER76-ASP84
RASP143-LYS163
RGLY232-ARG251
RPHE316-LEU360

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RVAL85-ALA105

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RVAL121-VAL142

site_idSWS_FT_FI6
Number of Residues19
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RPHE164-PHE183

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RMET209-TYR231

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RVAL252-ALA273

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RALA295-ALA315

site_idSWS_FT_FI10
Number of Residues1
DetailsSITE: (Microbial infection) Cleavage; by Staphylococcus aureus/SspP => ECO:0000269|PubMed:22850671
ChainResidueDetails
RASP35

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:9079638
ChainResidueDetails
RSER347
RSER351
RSER352
RSER353

site_idSWS_FT_FI12
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN22

222926

PDB entries from 2024-07-24

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