6LFM

Cryo-EM structure of a class A GPCR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	353	40283.8	1	UniProt (P63096) Pfam (PF00503) In PDB	Homo sapiens (Human)	Adenylate cyclase-inhibiting G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	346	38045.6	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (Human)	Transducin beta chain 1
3	C	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (Human)	G gamma-I
4	D, E	Interleukin-8	polymer	72	8401.8	2	UniProt (P10145) Pfam (PF00048) In PDB	Homo sapiens (Human)	IL-8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,GCP-1,Monocyte-derived neutrophil chemotactic factor,MDNCF,Monocyte-derived neutrophil-activating peptide,MONAP,Neutrophil-activating protein 1,NAP-1,Protein 3-10C,T-cell chemotactic factor
5	R	C-X-C chemokine receptor type 2	polymer	360	40798.1	1	UniProt (P25025) Pfam (PF00001) In PDB	Homo sapiens (Human)	CXCR-2,CDw128b,GRO/MGSA receptor,High affinity interleukin-8 receptor B,IL-8R B,IL-8 receptor type 2
6	S	scFv16	polymer	259	27784.9	1		Homo sapiens
7	R	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Ile -5	-	expression tag
Gly -4	-	expression tag
Arg -3	-	expression tag
Ala -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Phe 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	171577.2
Non-Polymers*	Number of molecules	1
	Total formula weight	386.7
All*	Total formula weight	171963.9

*Water molecules are not included.