6LFM
Cryo-EM structure of a class A GPCR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 353 | 40283.8 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38045.6 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D, E (D, E) | Interleukin-8 | polymer | 72 | 8401.8 | 2 | UniProt (P10145) Pfam (PF00048) | Homo sapiens (Human) | IL-8,C-X-C motif chemokine 8,Chemokine (C-X-C motif) ligand 8,Emoctakin,Granulocyte chemotactic protein 1,GCP-1,Monocyte-derived neutrophil chemotactic factor,MDNCF,Monocyte-derived neutrophil-activating peptide,MONAP,Neutrophil-activating protein 1,NAP-1,Protein 3-10C,T-cell chemotactic factor |
| 5 | F (R) | C-X-C chemokine receptor type 2 | polymer | 360 | 40798.1 | 1 | UniProt (P25025) Pfam (PF00001) | Homo sapiens (Human) | CXCR-2,CDw128b,GRO/MGSA receptor,High affinity interleukin-8 receptor B,IL-8R B,IL-8 receptor type 2 |
| 6 | G (S) | scFv16 | polymer | 259 | 27784.9 | 1 | Homo sapiens | ||
| 7 | H (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Ile -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Phe 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 171577.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 171963.9 |
